PSB-KK1445
PSB-KK1445 is a potent and selective GPR18 agonist with EC50s of 45.4 nM and 124 nM for human and mouse GPR18, respectively. PSB-KK1445 displays >200-fold selectivity versus both CB receptor subtypes, GPR55, and GPR183[1].
Product Specifications
CAS Number
885896-54-8
UNSPSC
12352005
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/psb-kk1445.html
Purity
99.47
Smiles
CN1C2=C(C(N(C1=O)C)=O)N(C(NCCC3=CNC4=C3C=CC=C4)=N2)CC5=CC=C(C=C5)F
Molecular Formula
C24H23FN6O2
Molecular Weight
446.48
References & Citations
[1]Andhika B Mahardhika, et al. Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity. J Med Chem. 2024 Jun 27;67 (12) :9896-9926.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
16704-AAT 200 µg
IFluor® 633 goat anti-rabbit IgG (H+L) *Cross Adsorbed*
Sign In for Pricing
View Details ![VSV-G-tag Mouse monoclonal Antibody [E0-G7]](https://cdn.genprice.uk/products/992/68dd1c8a061270361ea80dd6/imageurl/m1510-10-50ul.webp)
![2-[(2-Hydroxyethyl)octadecylamino]ethyl ester octadecanoic acid](https://cdn.genprice.uk/products/572/7943265152956/imageurl/trc-h998250-25mg.webp)
TRC-H998250-25MG 25 mg
2-[(2-Hydroxyethyl)octadecylamino]ethyl ester octadecanoic acid
Sign In for Pricing
View Details 