VHL Ligand 14
VHL Ligand 14 (Compound 11) is a VHL ligand for design of PROTAC estrogen receptor α (ERα) degraders, with a binding affinity IC50 of 196 nM[1].
Product Specifications
CAS Number
[2010986-87-3]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vhl-ligand-14.html
Purity
99.93
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@H]1N(C([C@@H](NC(C)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C
Molecular Formula
C25H34N4O4S
Molecular Weight
486.63
Precautions
H315, H319, H320
References & Citations
[1]Hu J, et al., Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER) . J Med Chem. 2019 Feb 14;62 (3) :1420-1442.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
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