VHL Ligand 14
Product Specifications
UNSPSC Description
VHL Ligand 14 (Compound 11) is a VHL ligand for design of PROTAC estrogen receptor α (ERα) degraders, with a binding affinity IC50 of 196 nM[1].
Target Antigen
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vhl-ligand-14.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C([C@H]1N(C([C@@H](NC(C)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C
Molecular Weight
486.63
References & Citations
[1]Hu J, et al., Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER). J Med Chem. 2019 Feb 14;62(3):1420-1442.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-150803/VHL-Ligand-14-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-150803/VHL-Ligand-14-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2010986-87-3
Available Sizes
Curated Selection
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