Pep19-2.5

Pep19-2.5 is an synthetic and antitoxin peptide, blocks the intracellular endotoxin signaling cascade. Pep19-2.5 inhibits signaling of lipopeptides (LP) and lipopolysaccharides (LPS) mediated by transmembrane and cytosolic pattern recognition receptors (PRRs) . The signaling cascades lead to inflammation and cell pyroptosis[1].

Product Specifications

CAS Number

[1322711-38-5]

UNSPSC

12352209

Target

Pyroptosis

Type

Peptides

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pep19-2-5.html

Purity

98.45

Solubility

10 mM in DMSO

Smiles

OC(CNC([C@H](CC1=CNC2=CC=CC=C12)NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC(CNC([C@H](CCCCN)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CS)NC(CN)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)CC5=CC=CC=C5)=O)=O)CC6=CNC7=CC=CC=C67)=O)=O)CC8=CC=CC=C8)=O)=O)=O)=O)CC9=CC=CC=C9)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)=O)=O)=O

Molecular Formula

C135H187N37O22S

Molecular Weight

2712.23

References & Citations

[1]Heinbockel L, et al. Inhibition of Lipopolysaccharide- and Lipoprotein-Induced Inflammation by Antitoxin Peptide Pep19-2.5. Front Immunol. 2018 Jul 26;9:1704. |[2]Bárcena-Varela S, et al. Coupling killing to neutralization: combined therapy with ceftriaxone/Pep19-2.5 counteracts sepsis in rabbits. Exp Mol Med. 2017 Jun 16;49 (6) :e345. |[3]Jannadi H, et al. Antimicrobial peptides Pep19-2.5 and Pep19-4LF inhibit Streptococcus mutans growth and biofilm formation. Microb Pathog. 2019 Aug;133:103546.