What is the catalog number for Dalazatide?

The catalog number for Dalazatide is HY-P3507.

What sizes are available for Dalazatide?

Dalazatide is available in the following size(s): 1 mg, 5 mg, 10 mg.

How many pack sizes does Dalazatide come in?

Dalazatide is available in 3 different pack sizes.

Is Dalazatide in stock?

Dalazatide is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Dalazatide?

Dalazatide is manufactured by QuantiMol.

What is the estimated delivery time for Dalazatide?

Estimated delivery time for Dalazatide is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Dalazatide?

The safety data sheet for Dalazatide is available here: http://file.medchemexpress.com/batch_PDF/HY-P3507/Dalazatide-SDS-MedChemExpress.pdf.

Dalazatide

Dalazatide (ShK-186) is a specific Kv1.3 potassium channel peptide inhibitor. Dalazatide can be used in the study of autoimmune diseases such as multiple sclerosis (MS), lupus erythematosus, psoriasis, rheumatoid arthritis, type 1 diabetes and inflammatory bowel disease[1][2][3].

Product Specifications

CAS Number

1081110-69-1

Product Name Alternative

ShK-186

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dalazatide.html

Purity

99.23

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC[C@@H]([C@@H]1NC([C@@H](NC([C@@H](NC([C@@](OCCOCCN)(N(C([C@H](Cc2ccc(OP(O)(O)=O)cc2)N)=O)C(C)=O)CCCNC(N)=N)=O)CO)=O)CSSC[C@@H](C(N)=O)NC([C@H]([C@H](O)C)NC(CNC(C3CSSC[C@@H]4NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]5CCCN5C([C@H]([C@H](CC)C)NC([C@H]([C@H](O)C)NC([C@@H](NC1=O)CC(O)=O)=O)=O)=O)=O)CCCCN)=O)CO)=O)CCCNC(N)=N)=O)CSSC[C@@H](C(NC(C(NC(C(N[C@H](C(N3)=O)[C@H](O)C)=O)CCCCN)=O)CCCNC(N)=N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC4=O)CCCCN)=O)Cc6nc[nH]c6)=O)CO)=O)CCSC)=O)CCCCN)=O)Cc7ccc(O)cc7)=O)CCCNC(N)=N)=O)CC(C)C)=O)CO)=O)Cc8ccccc8)=O)=O)=O)C)=O)Cc9ccccc9)=O)CCC(N)=O)=O)=O)=O)=O)=O)C

Molecular Formula

C184H296N57O55PS7

Molecular Weight

4442.10

References & Citations

[1]Olsen C, et al. Dalazatide (ShK-186), a first-in-class peptide inhibitor of Kv1. 3 potassium channels, demonstrates safety, tolerability and proof of concept of efficacy in patients with active plaque psoriasis. J. Invest. Dermatol., 2016, 136 (8) . |[2]Stevens A M, et al. Thu0285 Dalazatide, an Inhibitor of the KV1. 3 Channel on Activated Effector Memory T Cells, Has Immunotherapy Potential in Systemic Lupus Erythematosus. 2016. |[3]Matheu MP, et al. Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block. Immunity. 2008 Oct 17;29 (4) :602-14.