MER/TYRO3 (Phospho-Tyr753/Tyr685) Polyclonal Antibody

Rabbit Anti-MER/TYRO3 (Phospho-Tyr753/Tyr685) Polyclonal Antibody

Product Specifications

Background

MERTK (MER proto-oncogene, tyrosine kinase) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in MERTK have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP) .

CAS Number

9007-83-4

Product Name Alternative

MERTK MER

Gene ID

10461/7301

Accession Number

Q12866/Q06418

Reactivity

Human:Y753/Y685, Mouse:Y748/Y675, Rat:Y748/Y675

Immunogen

Synthetic peptide from human protein at AA range: 650-770

Clonality

Polyclonal

Tag

C-mer proto-oncogene tyrosine kinase

Applications

WB, ELISA, IHC

Purification Method

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Molecular Weight

110kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

The antibody detects endogenous MER/TYRO3 (Phospho-Tyr753/Tyr685) protein.

Observed Molecular Weight

110

Formulation

Liquid solution

Buffer pH

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000