Gallopamil

Gallopamil (Methoxyverapamil), a methoxy derivative of Verapamil, is a phenylalkylamine calcium antagonist[1]. Gallopamil inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM[2]. Gallopamil is a potent antiarrhythmic and vasodilator agent[3].

Product Specifications

CAS Number

[16662-47-8]

Product Name Alternative

Methoxyverapamil

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/gallopamil.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=C(OC)C(OC)=CC(C(CCCN(C)CCC2=CC(OC)=C(OC)C=C2)(C#N)C(C)C)=C1

Molecular Formula

C28H40N2O5

Molecular Weight

484.63

References & Citations

[1]Brogden RN, et al. Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease. Drugs. 1994 Jan;47 (1) :93-115.|[2]Sewing KF, et al. Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology. 1983;27 (1) :9-14.|[3]Kirchengast M, et al. Reperfusion arrhythmias in closed-chest rats: the effect of myocardial noradrenaline depletion and Ca2 (+) -antagonism. Clin Exp Pharmacol Physiol. 1991 Apr;18 (4) :217-21.