Cleaved-Caspase-4/5 p20 (D270/D311) Polyclonal Antibody

CASP4 (caspase 4) encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, caspase 4 induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

CASP4; ICH2; Caspase-4; CASP-4; ICE (rel) -II; Protease ICH-2; Protease TX; CASP5; ICH3; Caspase-5; CASP-5; ICE (rel) -III; Protease ICH-3; Protease TY

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Cleaved-Caspase-4/5 p20 (D270/D311) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-4/5 p20 protein resulting from cleavage adjacent to D270/D311.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.

CASP4; ICH2; Caspase-4; CASP-4; ICE (rel) -II; Protease ICH-2; Protease TX; CASP5; ICH3; Caspase-5; CASP-5; ICE (rel) -III; Protease ICH-3; Protease TY