GRK6-IN-1
GRK6-IN-1 (Compound 18) is the inhibitor for G protein-coupled receptorkinase 6 (GRK6) with an IC50 of 3.8-8 nM. GRK6-IN-1 also inhibits GRK7, GRK5, GRK4 and GRK1 with IC50s of 6.4, 12, 22 and 52 nM, respectively. GRK6-IN-1 has the potential for the research of multiple myeloma[1].
Product Specifications
CAS Number
2677786-61-5
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Aurora Kinase; G Protein-coupled Receptor Kinase (GRK) ; IGF-1R
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; GPCR/G Protein; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/grk6-in-1.html
Concentration
10mM
Purity
99.61
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC1=CC=CC2=NC(NCC3=CC=C(Cl)C=C3OC)=NC(NC4=NNC(CC)=C4)=C12
Molecular Formula
C22H23ClN6O2
Molecular Weight
438.91
Precautions
H315, H319, H320
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A
Available Sizes
Frequently Asked Questions
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