Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Rb (phospho Ser249) Polyclonal Antibody

Rabbit Anti-Rb (phospho Ser249) Polyclonal Antibody

Product Specifications

Background

The protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

CAS Number

9007-83-4

Product Name Alternative

RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

Gene ID

5925

Accession Number

P06400

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human Rb around the phosphorylation site of S249

Clonality

Polyclonal

Tag

Retinoblastoma-associated protein

Applications

WB, ELISA, IHC

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

Phospho-Rb (S249) Polyclonal Antibody detects endogenous levels of Rb protein only when phosphorylated at S249.

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000

Other Product Names

RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/P06400

Isotype

Rabbit IgG

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Neural Stem Cells (iPSC from Blood Cells; Male)
ASE-9234 1 vial (1 x 10^6)

Neural Stem Cells (iPSC from Blood Cells; Male)

Sign In for Pricing
View Details
Human KRT23 knockdown cell line
ABC-KD8108 1 Vial

Human KRT23 knockdown cell line

Sign In for Pricing
View Details
Mouse 2,3-dinor-TXB2 ELISA Kit
MBS269359-01 48 Well

Mouse 2,3-dinor-TXB2 ELISA Kit

Sign In for Pricing
View Details
Mouse 2,3-dinor-TXB2 ELISA Kit
MBS269359-02 96 Well

Mouse 2,3-dinor-TXB2 ELISA Kit

Sign In for Pricing
View Details
Mouse 2,3-dinor-TXB2 ELISA Kit
MBS269359-03 5x 96 Well

Mouse 2,3-dinor-TXB2 ELISA Kit

Sign In for Pricing
View Details
Mouse 2,3-dinor-TXB2 ELISA Kit
MBS269359-04 10x 96 Well

Mouse 2,3-dinor-TXB2 ELISA Kit

Sign In for Pricing
View Details