Spinosin

Spinosyn is a kind of effective C-saccharide, which has a protective effect. Spinosyn is active through Nrf2/HO-1 pathway inhibition Aβ1-42's production and combination[1][2][3].

Product Specifications

CAS Number

[72063-39-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/spinosin.html

Purity

99.39

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

COC1=C([C@H](O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H]2O[C@]([C@@H]([C@@H](O)[C@@H]3O)O)([H])O[C@@H]3CO)C(O)=C4C(OC(C5=CC=C(O)C=C5)=CC4=O)=C1

Molecular Formula

C28H32O15

Molecular Weight

608.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Jung IH, et al. Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice. Pharmacol Biochem Behav. 2014 May;120:88-94.|[2]Xu F, et al. Neuroprotective Effects of Spinosin on Recovery of Learning and Memory in a Mouse Model of Alzheimer's Disease. Biomol Ther (Seoul) . 2019 Jan 1;27 (1) :71-77.|[3]Zhang X, et al. Spinosin Inhibits Aβ1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway. Biomol Ther (Seoul) . 2019 Dec 3.