SLF80821178 (hydrochloride)

SLF80821178 hydrochloride is an orally active inhibitor for sphingosine-1-phosphate transporter (Spns2), that inhibits the sphingosine-1-phosphate (S1P) release in HeLa with an IC50 of 51 nM. SLF80821178 hydrochloride reduces the circulating lymphocyte without affecting plasma S1P levels in mice[1].

Product Specifications

CAS Number

[2764877-62-3]

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/slf80821178-hydrochloride.html

Smiles

O=C(N1CCNCC1)NC2=CC=C(CCCCCCCCCC)C=C2.Cl

Molecular Formula

C21H36ClN3O

Molecular Weight

381.98

References & Citations

[1]Foster DJ, et al., Discovery of Potent, Orally Bioavailable Sphingosine-1-Phosphate Transporter (Spns2) Inhibitors. J Med Chem. 2024 Jul 11;67 (13) :11273-11295.