S2P Polyclonal Antibody
Rabbit Anti-S2P Polyclonal Antibody
Product Specifications
Background
MBTPS2 (membrane bound transcription factor peptidase, site 2) encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in MBTPS2 have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome) ; IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.
CAS Number
9007-83-4
Product Name Alternative
MBTPS2; S2P; Membrane-bound transcription factor site-2 protease; Endopeptidase S2P; Sterol regulatory element-binding proteins intramembrane protease; SREBPs intramembrane protease
Gene ID
51360
Accession Number
O43462
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human S2P at AA range: 270-350
Clonality
Polyclonal
Tag
Membrane-bound transcription factor site-2 protease
Applications
WB, IP, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
S2P Polyclonal Antibody detects endogenous levels of S2P protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Other Product Names
MBTPS2; S2P; Membrane-bound transcription factor site-2 protease; Endopeptidase S2P; Sterol regulatory element-binding proteins intramembrane protease; SREBPs intramembrane protease
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O43462
Isotype
Rabbit IgG
Available Sizes
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