Glycerol phenylbutyrate
Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand, with a pKi of 8.02. Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger agent[1][2].
Product Specifications
CAS Number
[611168-24-2]
Product Name Alternative
HPN-100
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Glycerol_phenylbutyrate.html
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)
Smiles
O=C(CCCC1=CC=CC=C1)OC(COC(CCCC2=CC=CC=C2)=O)COC(CCCC3=CC=CC=C3)=O
Molecular Formula
C33H38O6
Molecular Weight
530.65
Precautions
H302, H315, H319, H335
References & Citations
[1]Rescifina A, et al. Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis. Eur J Pharm Sci. 2017 Aug 30;106:94-101.|[2]Oishi K, et al. Glycerol phenylbutyrate for the chronic management of urea cycle disorders. Expert Rev Endocrinol Metab. 2014 Sep;9 (5) :427-434.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Sigma 2 Receptor
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
K0378404 1.0 µg DNA
CCDC65 sgRNA CRISPR Lentivector (Human) (Target 3)
Sign In for Pricing
View Details 133522-AP 100 µL
SLIT3 (Slit Homolog 3 Protein, Slit-3, Multiple Epidermal Growth Factor-like Domains Protein 5, Multiple EGF-like Domains Protein 5, KIAA0814, MEGF5, SLIL2, UNQ691/PRO1336, FLJ10764) (AP) discontinued
Sign In for Pricing
View Details 
406225-01 50 µL
CEP57L1 (Centrosomal Protein CEP57L1, Centrosomal Protein 57kD-like Protein 1, Centrosomal Protein of 57kD-related protein, Cep57R, Cep57-related Protein, CEP57L1, C6orf182, CEP57R)
Sign In for Pricing
View Details 406225-02 100 µL
CEP57L1 (Centrosomal Protein CEP57L1, Centrosomal Protein 57kD-like Protein 1, Centrosomal Protein of 57kD-related protein, Cep57R, Cep57-related Protein, CEP57L1, C6orf182, CEP57R)
Sign In for Pricing
View Details RC225649L3 10 µg
Activin A Receptor Type IC (ACVR1C) (NM_001111032) Human Tagged Lenti ORF Clone
Sign In for Pricing
View Details