Glycerol phenylbutyrate

Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand, with a pKi of 8.02. Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger agent[1][2].

Product Specifications

CAS Number

[611168-24-2]

Product Name Alternative

HPN-100

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Glycerol_phenylbutyrate.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)

Smiles

O=C(CCCC1=CC=CC=C1)OC(COC(CCCC2=CC=CC=C2)=O)COC(CCCC3=CC=CC=C3)=O

Molecular Formula

C33H38O6

Molecular Weight

530.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Rescifina A, et al. Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis. Eur J Pharm Sci. 2017 Aug 30;106:94-101.|[2]Oishi K, et al. Glycerol phenylbutyrate for the chronic management of urea cycle disorders. Expert Rev Endocrinol Metab. 2014 Sep;9 (5) :427-434.