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Na+/K+-ATPase α2 Polyclonal Antibody

Rabbit Anti-Na+/K+-ATPase α2 Polyclonal Antibody

Product Specifications

Background

The protein encoded by ATP1A2 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. ATP1A2 encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.

CAS Number

9007-83-4

Product Name Alternative

ATP1A2; KIAA0778; Sodium/potassium-transporting ATPase subunit alpha-2; Na (+) /K (+) ATPase alpha-2 subunit; Sodium pump subunit alpha-2

Gene ID

477

Accession Number

P50993

Reactivity

Human, Mouse, Rat, Monkey

Immunogen

Synthesized peptide derived from the C-terminal region of human Na+/K+-ATPase α2 at AA range: 940-1020

Clonality

Polyclonal

Tag

Sodium potassium-transporting ATPase subunit alpha-2

Applications

WB, ELISA, IHC

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

112kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

Na+/K+-ATPase α2 Polyclonal Antibody detects endogenous levels of Na+/K+-ATPase α2 protein.

Product Datasheet

https://www.abbkine.com/datasheet/ABP55363.pdf

Observed Molecular Weight

112

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300; ELISA 1:2000-20000

Other Product Names

ATP1A2; KIAA0778; Sodium/potassium-transporting ATPase subunit alpha-2; Na (+) /K (+) ATPase alpha-2 subunit; Sodium pump subunit alpha-2

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/P50993

Isotype

Rabbit IgG

Available Sizes

Curated Selection

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