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Bisantrene (dihydrochloride)

Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1[1][2][3][4].

Product Specifications

CAS Number

71439-68-4

Product Name Alternative

CL-216942 (dihydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H400

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bisantrene-dihydrochloride.html

Purity

98.85

Solubility

DMSO : 5 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H]Cl.[H]Cl.C12=CC=CC=C1C(/C=N/NC3=NCCN3)=C4C(C=CC=C4)=C2/C=N/NC5=NCCN5

Molecular Formula

C22H24Cl2N8

Molecular Weight

471.39

Precautions

H302, H400

References & Citations

[1]Sissi C, et al. DNA-binding preferences of Bisantrene analogues: relevance to the sequence specificity of drug-mediated topoisomerase II poisoning. Mol Pharmacol. 1998 Dec;54 (6) :1036-45.|[2]Yap HY, et al. Bisantrene, an active new drug in the treatment of metastatic breast cancer. Cancer Res. 1983 Mar;43 (3) :1402-4.|[3]Wang BS, et al. Activation of tumor-cytostatic macrophages with the antitumor agent 9,10-anthracenedicarboxaldehyde bis[ (4,5-dihydro-1H-imidazole-2-yl) hydrazone] dihydrochloride (bisantrene) . Cancer Res. 1984 Jun;44 (6) :2363-7. |[4]Aksentijevich I, et al. Retroviral transfer of the human MDR1 gene confers resistance to bisantrene-specific hematotoxicity. Clin Cancer Res. 1996 Jun;2 (6) :973-80.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Citation 01

Mol Cancer. 2024 Dec 20;23 (1) :275.|Anal Chem. 2022 Mar 22;94 (11) :4695-4702.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|Mol Cell. 2021 Mar 4;81 (5) :922-939.e9.|Nat Commun. 2021 Apr 12;12 (1) :2183.|Research Square Preprint. 2021 Aug.

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