Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Mdm2 Polyclonal Antibody

Rabbit Anti-Mdm2 Polyclonal Antibody

Product Specifications

Background

MDM2 encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Product Name Alternative

MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2

Gene ID

4193

Accession Number

Q00987

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from the C-terminal region of human Mdm2 at AA rangle: 360-440

Clonality

Polyclonal

Tag

E3 ubiquitin-protein ligase Mdm2

Applications

WB, IHC, IF, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

90kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

Mdm2 Polyclonal Antibody detects endogenous levels of Mdm2 protein.

Product Datasheet

https://www.abbkine.com/datasheet/ABP55212.pdf

Observed Molecular Weight

90

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications.

Other Product Names

MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2

Tested Applications

WB, IHC, IF, IP, ELISA

Host or Source

Rabbit

Accession Number URL

http://www.uniprot.org/uniprot/Q00987

CAS Number

9007-83-4

Isotype

Rabbit IgG

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Apolipoprotein B (APOB) Mouse Monoclonal Antibody [Clone ID: 1605]
BM2149 1 mg

Apolipoprotein B (APOB) Mouse Monoclonal Antibody [Clone ID: 1605]

Ask
View Details
6-Bromo-2-morpholinopyridine
OR300693-01 250 mg

6-Bromo-2-morpholinopyridine

Ask
View Details
6-Bromo-2-morpholinopyridine
OR300693-02 5 g

6-Bromo-2-morpholinopyridine

Ask
View Details
6-Bromo-2-morpholinopyridine
OR300693-03 25 g

6-Bromo-2-morpholinopyridine

Ask
View Details
6-Bromo-2-morpholinopyridine
OR300693-04 100 g

6-Bromo-2-morpholinopyridine

Ask
View Details
PE/Cyanine5 Anti-Mouse IgD Antibody
MBS4514793-01 20 Tests

PE/Cyanine5 Anti-Mouse IgD Antibody

Ask
View Details