What is the catalog number for MDM2 (phospho Ser186/S188) Polyclonal Antibody?

The catalog number for MDM2 (phospho Ser186/S188) Polyclonal Antibody is ABP55211.

What sizes are available for MDM2 (phospho Ser186/S188) Polyclonal Antibody?

MDM2 (phospho Ser186/S188) Polyclonal Antibody is available in the following size(s): 30 µL, 100 µL, 200 µL.

How many pack sizes does MDM2 (phospho Ser186/S188) Polyclonal Antibody come in?

MDM2 (phospho Ser186/S188) Polyclonal Antibody is available in 3 different pack sizes.

Is MDM2 (phospho Ser186/S188) Polyclonal Antibody in stock?

MDM2 (phospho Ser186/S188) Polyclonal Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

MDM2 (phospho Ser186/S188) Polyclonal Antibody

Rabbit Anti-MDM2 (phospho Ser186/S188) Polyclonal Antibody

Product Specifications

Background

MDM2 encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. MDM2 is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

CAS Number

9007-83-4

Product Name Alternative

MDM2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein; Hdm2; Oncoprotein Mdm2; p53-binding protein Mdm2

Gene ID

4193

Accession Number

Q00987

Reactivity

Human, Rat, Mouse

Immunogen

Synthesized peptide derived from human MDM2 around the phosphorylation site of S186/S188

Clonality

Polyclonal

Tag

E3 ubiquitin-protein ligase Mdm2

Applications

IF, WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

Phospho-MDM2 (S186/S188) Polyclonal Antibody detects endogenous levels of MDM2 protein only when phosphorylated at S186/S188.

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.