ATG4b Rabbit rabbit pAb

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

Q9Y4P1

Swiss Prot

Q9Y4P1

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Protein of ATG4b

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF

Concentration

1 mg/ml

Dilution

IHC-p 1:50-300

Molecular Weight

44kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

44kD

Fragment

IgG

Subcellular Location

Cytoplasm . Cytoplasm, cytosol . Cytoplasmic vesicle, autophagosome . Endoplasmic reticulum . Mitochondrion . Mainly localizes to the cytoplasm, including cytosol (PubMed:29165041) . A samll potion localizes to mitochondria; phosphorylation at Ser-34 promotes localization to mitochondria (PubMed:29165041) . .

Other Product Names

Cysteine protease ATG4B (EC 3.4.22.-; AUT-like 1 cysteine endopeptidase; Autophagin-1; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; hAPG4B)