2,6-Dibromophenol

2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca2+ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC50 of 2.78 mg/L for Daphnia magna and a 96 h EC50 of 9.90 mg/L for algae (Scenedesmus quadricauda) [1][2].

Product Specifications

CAS Number

[608-33-3]

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Calcium Channel; Fungal; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-6-dibromophenol.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=C(Br)C=CC=C1Br

Molecular Formula

C6H4Br2O

Molecular Weight

251.91

Precautions

H302+H312+H332

References & Citations

[1]Hassenklöver T, et al. Bromophenols, both present in marine organisms and in industrial flame retardants, disturb cellular Ca2+ signaling in neuroendocrine cells (PC12) . Aquat Toxicol. 2006 Jan 5;76 (1) :37-45.|[2]Li B, et al. Acute Toxicities of Bromophenols to Alga and Daphina: Comparative Species Sensitivity Distribution Between Standard and Dietary Supplementation Tests. J Toxicol. 2025 May 11;2025:3399746.