HPGDS inhibitor 1
HPGDS inhibitor 1 is a potent, selective and orally active Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50s of 0.6 nM and 32 nM in enzyme and cellular assays, respectively. HPGDS inhibitor 1 does not inhibit human L-PGDS, mPGES, COX-1, COX-2, or 5-LOX[1].
Product Specifications
CAS Number
[1033836-12-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H320, H335
Target
PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hpgds-inhibitor-1.html
Purity
99.42
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1CCN(CC(F)(F)F)CC1)C2=CC=C(C3=CC=CC(F)=C3)N=C2
Molecular Formula
C19H19F4N3O
Molecular Weight
381.37
Precautions
H302, H315, H320, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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