NVP-DFF332
HIF-2α-IN-8 is a potent and orally active HIF2α inhibitor with IC50 values of 9, 37, 246 nM for HIF2α SPA, HIF2α iScript, HIF2α HRE RGA, respectively. HIF-2α-IN-8 shows antitumor activity[1].
Product Specifications
CAS Number
[2734922-78-0]
Product Name Alternative
HIF-2α-IN-8
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hif-2α-in-8.html
Purity
99.31
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
FC1(C2=C(Cl)N=CC=C2[C@]3(CC1)N=C4N(C=C(C=C4OC(F)F)C(F)(F)F)C3)F
Molecular Formula
C17H11ClF7N3O
Molecular Weight
441.73
References & Citations
[1]Robin Alec Fairhurst, et al. Compounds and compositions for inhibiting the activity of hif2-alpha and their methods of use. WO2021220170A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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