Fhit (phospho Tyr114) Polyclonal Antibody
Rabbit Anti-Fhit (phospho Tyr114) Polyclonal Antibody
Product Specifications
Background
FHIT, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1, P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.
CAS Number
9007-83-4
Product Name Alternative
FHIT; Bis (5'-adenosyl) -triphosphatase; AP3A hydrolase; AP3Aase; Diadenosine 5'; 5'''-P1, P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein
Gene ID
2272
Accession Number
P49789
Reactivity
Human, Rat, Mouse
Immunogen
Synthesized peptide derived from human Fhit around the phosphorylation site of Y114
Clonality
Polyclonal
Tag
Bis (5'-adenosyl) -triphosphatase
Applications
IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Phospho-Fhit (Y114) Polyclonal Antibody detects endogenous levels of Fhit protein only when phosphorylated at Y114.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200
Other Product Names
FHIT; Bis (5'-adenosyl) -triphosphatase; AP3A hydrolase; AP3Aase; Diadenosine 5'; 5'''-P1, P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P49789
Isotype
Rabbit IgG
Available Sizes
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