VU0463841
VU0463841 is a potent, selective and brain-penetrant mGlu5 negative allosteric modulator (NAM) with an IC50 of 13 nM. VU0463841 is ineffective against mGlu1-4 and mGlu7-8. VU0463841 has the potential for the Cocaine addiction research[1].
Product Specifications
CAS Number
1439095-16-5
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0463841.html
Smiles
O=C(NC1=NC=C(C=C1)Cl)NC2=CC(F)=CC(C#N)=C2
Molecular Formula
C13H8ClFN4O
Molecular Weight
290.68
References & Citations
[1]Russell J Amato, et al. Substituted 1-Phenyl-3- (pyridin-2-yl) urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction. ACS Chem Neurosci. 2013 Aug 21;4 (8) :1217-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
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