Thalidomide-5-O-CH2-COOH

Thalidomide-5-O-CH2-COOH is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-5-O-CH2-COOH acts as a ligand for Cereblon to recruit CRBN protein. Thalidomide-5-O-CH2-COOH is a key intermediate in the synthesis of PROTAC molecules designed based on CRBN.

Product Specifications

CAS Number

[2467425-53-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-5-o-ch2-cooh.html

Purity

97.0

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)COC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1

Molecular Formula

C15H12N2O7

Molecular Weight

332.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53. [Content Brief]