SBN-284

SBN-284 (compound 3x) is a dual inhibitor of blood-brain permeable Cholinesterases and the NLRP3 inflammasome and is effective against EeAChE, hAChE and eqBChE, the IC50 values of are 0.37, 0.31, 0.29 μM respectively, and the EC50 of NLRP3 inflamm is 1 μM. SBN-284 can be used in Alzheimer's disease research[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE) ; NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sbn-284.html

Smiles

CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(NCCC4CCN(CC5=CC=CC=C5)CC4)C2=O)=O

Molecular Formula

C35H43N3O5

Molecular Weight

585.73

References & Citations

[1]Reddy CN, et al. Synthesis and Biological Evaluation of Colchicine─Aryl/Alkyl Amine Hybrids as Potential Noncytotoxic Cholinesterase Inhibitors: Identification of SBN-284 as a Dual Inhibitor of Cholinesterases and NLRP3 Inflammasome. ACS Chem Neurosci. 2024 Aug 7;15 (15) :2779-2794.