4.1R (phospho Tyr660) Polyclonal Antibody

Rabbit Anti-4.1R (phospho Tyr660) Polyclonal Antibody

Product Specifications

Background

The erythrocyte membrane protein band 4. encoded by EPB41, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1) . Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

CAS Number

9007-83-4

Product Name Alternative

EPB41; E41P; Protein 4.1; P4.1; 4.1R; Band 4.1; EPB4.1

Gene ID

2035

Accession Number

P11171

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from human 4.1R around the phosphorylation site of Y660

Clonality

Polyclonal

Tag

Protein 4.1

Applications

WB, IHC, IF, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

60kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

Phospho-4.1R (Y660) Polyclonal Antibody detects endogenous levels of 4.1R protein only when phosphorylated at Y660.

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200