PD0325901-O-C2-dioxolane

PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader[1].

Product Specifications

CAS Number

[2581116-22-3]

UNSPSC

12352005

Target

Ligands for Target Protein for PROTAC; MEK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd0325901-o-c2-dioxolane.html

Purity

98.62

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NOCCC1OCCO1)C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F

Molecular Formula

C18H16F3IN2O4

Molecular Weight

508.23

References & Citations

[1]Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader. J Med Chem. 2019;62 (23) :10897-10911.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MEK1; MEK2

Available Sizes

Curated Selection

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