PD0325901-O-C2-dioxolane
Product Specifications
UNSPSC Description
PD0325901-O-C2-dioxolane has main portion of MEK inhibitor PD0325901. PD0325901-O-C2-dioxolane and a ligand of VHL or CRBN E3 ligase can be used in the synthesis of MEK1/2 degrader[1].
Target Antigen
Ligands for Target Protein for PROTAC; MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway;PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pd0325901-o-c2-dioxolane.html
Purity
98.76
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NOCCC1OCCO1)C2=CC=C(F)C(F)=C2NC3=CC=C(I)C=C3F
Molecular Weight
508.23
References & Citations
[1]Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader. J Med Chem. 2019;62(23):10897-10911.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131295/PD0325901-O-C2-dioxolane-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131295/PD0325901-O-C2-dioxolane-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2581116-22-3
Available Sizes
Curated Selection
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