Isogarcinol

Isogarcinol (Cambogin) is a potent AChE and BChE inhibitor, with IC50 values of 1.13 and 8.30 μM, respectively. Isogarcinol also shows leishmanicidal activity, with an IC50 of 0.33 μM against L. donovani[1].

Product Specifications

CAS Number

[71117-97-0]

Product Name Alternative

Cambogin

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/isogarcinol.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@@]23C(OC(C)([C@H](C3)C/C=C(C)\C)C)=C(C([C@@]1(C(C)([C@@H](C2)C/C=C(C)\C)C)C/C=C(C)\C)=O)C(C4=CC(O)=C(C=C4)O)=O

Molecular Formula

C38H50O6

Molecular Weight

602.80

References & Citations

[1]Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12 (8) :1548-57.