ZnT-8 Polyclonal Antibody

Rabbit Anti-ZnT-8 Polyclonal Antibody

Product Specifications

Background

Zinc transporter 8 encoded by SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. SLC30A8 is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM) . Several transcript variants encoding different isoforms have been found for this gene.

CAS Number

9007-83-4

Product Name Alternative

SLC30A8; ZNT8; Zinc transporter 8; ZnT-8; Solute carrier family 30 member 8

Gene ID

169026

Accession Number

Q8IWU4

Reactivity

Human, Rat, Mouse

Immunogen

Synthesized peptide derived from the Internal region of human ZnT-8 at AA rangle: 140-220

Clonality

Polyclonal

Tag

Zinc transporter 8

Applications

WB, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

41kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

ZnT-8 Polyclonal Antibody detects endogenous levels of ZnT-8 protein.

Observed Molecular Weight

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.