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Dynorphin A (1-8)

Dynorphin A (1-8) is the predominant opioid peptide identified in placental tissue extracts. Dynorphin A (1-8) is the most likely natural ligand of the kappa receptor. The binding of 3H-Bremazocine to the purified kappa receptor is inhibited by Dynorphin A (1-8) (IC50=303 nM) [1][2].

Product Specifications

CAS Number

75790-53-3

UNSPSC

12352209

Target

Endogenous Metabolite; Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dynorphin-a-1-8.html

Purity

99.88

Solubility

10 mM in DMSO

Smiles

O=C(NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC2=CC=C(C=C2)O)N

Molecular Formula

C46H72N14O10

Molecular Weight

981.15

References & Citations

[1]Agbas A, Ahmed MS, Millington W, et al. Dynorphin A (1-8) in human placenta: amino acid sequence determined by tandem mass spectrometry. Peptides. 1995;16 (4) :623-627.|[2]Ahmed MS, Zhou DH, Cavinato AG, Maulik D. Opioid binding properties of the purified kappa receptor from human placenta. Life Sci. 1989;44 (13) :861-871.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, stored under nitrogen, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite; κ Opioid Receptor/KOR

Available Sizes

Frequently Asked Questions

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