L-p-Boronophenylalanine
L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (LAT1 and LAT2) . L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT) . When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma[1][2].
Product Specifications
CAS Number
[76410-58-7]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Biochemical Assay Reagents
Type
Peptides
Related Pathways
Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/l-p-boronophenylalanine.html
Purity
99.84
Solubility
1 M HCl : 10 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCl; heat to 60°C) |DMSO : 10.94 mg/mL (ultrasonic; adjust pH to 2 with 1 M HCl)
Smiles
O=C(O)[C@@H](N)CC1=CC=C(B(O)O)C=C1
Molecular Formula
C9H12BNO4
Molecular Weight
209.01
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
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STUB1 (STIP1 Homology and U box-containing Protein 1, E3 Ubiquitin-protein Ligase CHIP, Antigen NY-CO-7, CLL-associated Antigen KW-8, Carboxy Terminus of Hsp70-interacting Protein, CHIP, PP1131, HSPABP2, NY-CO-7, SDCCAG7, UBOX1) (FITC)
STUB1 (STIP1 Homology and U box-containing Protein 1, E3 Ubiquitin-protein Ligase CHIP, Antigen NY-CO-7, CLL-associated Antigen KW-8, Carboxy Terminus of Hsp70-interacting Protein, CHIP, PP1131, HSPABP2, NY-CO-7, SDCCAG7, UBOX1) (FITC)