Talnetant
Talnetant (SB 223412) is a selective, competitive, brain-permeable NK3 receptor antagonist with a Ki of 1.4 nM in hNK-3-CHO cells. Talnetant is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant can be used in schizophrenia-related studies[1][2][3].
Product Specifications
CAS Number
174636-32-9
Product Name Alternative
SB 223412
UNSPSC
12352005
Hazard Statement
H301
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Talnetant.html
Concentration
10mM
Purity
99.48
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC1=C(C(N[C@H](C2=CC=CC=C2)CC)=O)C3=C(N=C1C4=CC=CC=C4)C=CC=C3
Molecular Formula
C25H22N2O2
Molecular Weight
382.45
Precautions
H301
References & Citations
[1]Giardina GA, et al. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 2. Identification of (S) -N- (1-phenylpropyl) -3-hydroxy-2-phenylquinoline-4-carboxamide (SB 223412) . J Med Chem. 1999 Mar 25;42 (6) :1053-65.|[2]Houghton LA, et al. Effect of the NK (3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans. Neurogastroenterol Motil. 2007 Sep;19 (9) :732-43.|[3]Dawson LA, et al. In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant) : potential therapeutic utility in the treatment of schizophrenia. Neuropsychopharmacology. 2008 Jun;33 (7) :1642-52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NK3R
Available Sizes
Frequently Asked Questions
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