OAS2 Polyclonal Antibody

Rabbit Anti-OAS2 Polyclonal Antibody

Product Specifications

Background

OAS2 encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The 2'-5'-oligoadenylate synthetase 2 is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As) . These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.

CAS Number

9007-83-4

Product Name Alternative

OAS2; 2'-5'-oligoadenylate synthase 2; (2-5') oligo (A) synthase 2; 2-5A synthase 2; p69 OAS / p71 OAS; p69OAS / p71OAS

Gene ID

4939

Accession Number

P29728

Reactivity

Human, Rat, Mouse

Immunogen

Synthesized peptide derived from the N-terminal region of human OAS2

Clonality

Polyclonal

Tag

2'-5'-oligoadenylate synthase 2

Applications

WB, IHC, IF, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

82kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

OAS2 Polyclonal Antibody detects endogenous levels of OAS2 protein.

Observed Molecular Weight

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200