Tri-GalNAc (OAc) 3-Perfluorophenyl

Tri-GalNAc (OAc) 3-Perfluorophenyl is a pentafluorophenyl modified Tri-GalNAc (OAc) 3 (HY-148118), a tri-GalNAc ligand that can be used for the synthesis of GalNAc-LYTAC. GalNAc-LYTAC engages the asialoglycoprotein receptor for targeted protein degradation.Tri-GalNAc (OAc) 3-Perfluorophenyl can be used for the study of liver metabolism[1].

Product Specifications

UNSPSC

12352005

Target

LYTACs

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tri-galnac-oac-3-perfluorophenyl.html

Purity

95.0

Solubility

10 mM in DMSO|DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(CCOCCOCCOCCOCCOCCC(OC1=C(F)C(F)=C(F)C(F)=C1F)=O)NC(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]2COC(C)=O)[C@@H]([C@H]([C@H]2OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]3COC(C)=O)[C@@H]([C@H]([C@H]3OC(C)=O)OC(C)=O)NC(C)=O)=O)=O)COCCC(NCCCNC(CCCCO[C@H](O[C@@H]4COC(C)=O)[C@@H]([C@H]([C@H]4OC(C)=O)OC(C)=O)NC(C)=O)=O)=O

Molecular Formula

C99H151F5N10O44

Molecular Weight

2280.29

References & Citations

[1]Zhou Y, et al. Development of Triantennary N-Acetylgalactosamine Conjugates as Degraders for Extracellular Proteins. ACS Cent Sci. 2021 Mar 24;7 (3) :499-506.