BI-9787

BI-9787 is a zwitterionic inhibitior for ketohexokinase, with an IC50 of 12 and 12.8 nM for hKHK-A and hKHK-C. BI-9787 exhibits good metabolic stability in rat hepatocyte and good pharmacokinetic characteristics in rats[1].

Product Specifications

CAS Number

[3043939-18-7]

UNSPSC

12352005

Target

Ketohexokinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bi-9787.html

Purity

97.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CSC1=CC=C(C[C@@H](C(O)=O)C)C=C1NC2=C(C#N)C(C(F)F)=CC(N3CC[C@H](N(C)C)C3)=N2

Molecular Formula

C24H29F2N5O2S

Molecular Weight

489.58

References & Citations

[1]Heine N, et al., Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability. Bioorg Med Chem Lett. 2024 Aug 22;112:129930.