BI-9787
BI-9787 is a zwitterionic inhibitior for ketohexokinase, with an IC50 of 12 and 12.8 nM for hKHK-A and hKHK-C. BI-9787 exhibits good metabolic stability in rat hepatocyte and good pharmacokinetic characteristics in rats[1].
Product Specifications
CAS Number
[3043939-18-7]
UNSPSC
12352005
Target
Ketohexokinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bi-9787.html
Purity
97.82
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CSC1=CC=C(C[C@@H](C(O)=O)C)C=C1NC2=C(C#N)C(C(F)F)=CC(N3CC[C@H](N(C)C)C3)=N2
Molecular Formula
C24H29F2N5O2S
Molecular Weight
489.58
References & Citations
[1]Heine N, et al., Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability. Bioorg Med Chem Lett. 2024 Aug 22;112:129930.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Badge
Hot
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6140893-01 0.1 mL
C4B (Complement C4-B, Basic Complement C4, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 3, CO4, CPAMD3) (Biotin)
Ask
View Details MBS6140893-02 5x 0.1 mL
C4B (Complement C4-B, Basic Complement C4, C3 and PZP-like alpha-2-macroglobulin Domain-containing Protein 3, CO4, CPAMD3) (Biotin)
Ask
View Details MBS6397779-01 0.1 mL
TYRP1 (Tyrosinase-related Protein 1, TRP1, TRP-1, TRP, TYRP, TYRRP, 5,6-dihydroxyindole-2-carboxylic Acid Oxidase, DHICA Oxidase, Catalase B, CATB, CAS2, Glycoprotein 75, GP75, Melanoma Antigen gp75) (FITC)
Ask
View Details