N2-Phenoxyacetylguanosine

N2-Phenoxyacetylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1].

Product Specifications

CAS Number

[119824-66-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n2-phenoxyacetylguanosine.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(N=C(NC(COC3=CC=CC=C3)=O)NC4=O)=C4N=C2)O[C@@H]1CO

Molecular Formula

C18H19N5O7

Molecular Weight

417.37

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100 (11) :6646-51.