Deoxyarbutin

Deoxyarbutin is an orally active tyrosinase inhibitor that can promote apoptosis of melanoma cells, enhance the vitality of mouse acinar cells, and has skin whitening and anti-tumor activity[1][2][3].

Product Specifications

CAS Number

[53936-56-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Tyrosinase

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Deoxyarbutin.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(OC2CCCCO2)C=C1

Molecular Formula

C11H14O3

Molecular Weight

194.23

Precautions

H302, H315, H319, H335

References & Citations

[1]Boissy RE, et al. DeoxyArbutin: a novel reversible tyrosinase inhibitor with effective in vivo skin lightening potency. Exp Dermatol. 2005 Aug;14 (8) :601-8. |[2]Ma L, et al. Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38-mediated mitochondria associated apoptotic pathway. Sci Rep. 2017 Aug 3;7 (1) :7197. |[3]Li Y, et al. Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2/PGC-1α pathway. Free Radic Res. 2022 Sep-Oct;56 (9-10) :651-665.