Alectinib analog
Alectinib analog (CH5424802 analog) is a selective ALK inhibitor with activity in blocking resistance gating mutations. The synthetic optimization of alectinib analog allows it to be combined with specific peptides to improve the ability to target cancer cells. Alectinib analog exhibits low micromolar IC50 values in antiproliferation and shows good cytotoxic effects. The inhibitory activity of alectinib analog is closely related to its stability and release of active ingredients. Alectinib analog demonstrated the ability to inhibit vascular septal length or width in an in vivo zebrafish model[1].
Product Specifications
CAS Number
1256577-71-5
Product Name Alternative
CH5424802 analog; RO5424802 analog; RG7853 analog
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK)
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alectinib-analog.html
Smiles
N#CC1=CC(NC2=C3C(C4=CC=C(N5CCC(CC5)N6CCOCC6)C=C4C2(C)C)=O)=C3C=C1
Molecular Formula
C28H30N4O2
Molecular Weight
454.56
References & Citations
[1]Synthesis and Anti-Angiogenic Activity of Novel c (RGDyK) Peptide-Based JH-VII-139-1 Conjugates
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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