URMC-099

URMC-099 is an orally bioavailable and potent mixed lineage kinase type 3 (MLK3) (IC50=14 nM) inhibitor with with excellent blood-brain barrier penetration properties.

Product Specifications

CAS Number

[1229582-33-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Mixed Lineage Kinase

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/URMC-099.html

Concentration

10mM

Purity

98.69

Solubility

DMSO : ≥ 33 mg/mL

Smiles

CN(CC1)CCN1CC(C=C2)=CC=C2C3=CN=C4C(C(C5=CC=C(NC=C6)C6=C5)=CN4)=C3

Molecular Formula

C27H27N5

Molecular Weight

421.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Goodfellow VS, et al. Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem. 2013 Oct 24;56 (20) :8032-48.|[2]Rhoo KH, et al. Pharmacologic inhibition of MLK3 kinase activity blocks the in vitro migratory capacity of breast cancer cells but has no effect on breast cancer brain metastasis in a mouse xenograft model. PLoS One. 2014 Sep 29;9 (9) :e108487.