Neurofibromin Polyclonal Antibody

Rabbit Anti-Neurofibromin Polyclonal Antibody

Product Specifications

Background

NF1 product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.

CAS Number

9007-83-4

Product Name Alternative

NF1; Neurofibromin; Neurofibromatosis-related protein NF-1

Gene ID

4763

Accession Number

P21359

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from the Internal region of human Neurofibromin at AA range: 1520-1600

Clonality

Polyclonal

Tag

Neurofibromin

Applications

WB, IHC

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

319kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

Neurofibromin Polyclonal Antibody detects endogenous levels of Neurofibromin protein.

Observed Molecular Weight

319

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000; IHC 1:50-300