GSK3β Polyclonal Antibody

Rabbit Anti-GSK3β Polyclonal Antibody

Product Specifications

Background

Glycogen synthase kinase-3 beta encoded by GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. Glycogen synthase kinase-3 beta is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in GSK3B have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for GSK3B.

CAS Number

9007-83-4

Product Name Alternative

GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B

Gene ID

2932

Accession Number

P49841

Reactivity

Human, Mouse, Rat, Rabbit

Immunogen

Synthesized peptide derived from human GSK3β around the non-phosphorylation site of S9

Clonality

Polyclonal

Tag

Glycogen synthase kinase-3 beta

Applications

IF, WB, IHC, IP, ELISA

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Molecular Weight

47kD

Precautions

The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Shipping Conditions

Gel pack with blue ice.

Storage Conditions

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Notes

GSK3β Polyclonal Antibody detects endogenous levels of GSK3β protein.

Observed Molecular Weight

Formulation

Liquid solution

Buffer pH

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Applications Notes

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF 1:50-200; WB 1:500-1:2000; IHC 1:100-1:300; IP 2-5 ug:mg lysate; ELISA 1:20000; Not yet tested in other applications