Nor-NOHA (acetate)

Nor-NOHA acetate is a selective and reversible arginase inhibitor. nor-NOHA acetate induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA acetate has anti-leukemic activity. nor-NOHA acetate improves liver ischemia-reperfusion injury. nor-NOHA acetate can used in study of tuberculosis, endothelial dysfunction, immunosuppression and metabolism[1][2][3][4].

Product Specifications

CAS Number

[1140844-63-8]

Product Name Alternative

Nω-Hydroxy-nor-L-arginine (acetate)

UNSPSC

12352211

Target

Apoptosis; Arginase

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/nor-NOHA_acetate.html

Concentration

10mM

Purity

99.5

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O)[C@@H](N)CCNC(NO)=N.CC(O)=O.CC(O)=O

Molecular Formula

C9H20N4O7

Molecular Weight

296.28

References & Citations

[1]Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13 (10) :e0205254.|[2]Jung C, et al. Arginase inhibition mediates cardioprotection during ischaemia-reperfusion. Cardiovasc Res. 2010 Jan 1;85 (1) :147-54.|[3]Reid KM, et al. Liver I/R injury is improved by the arginase inhibitor, N (omega) -hydroxy-nor-L-arginine (nor-NOHA) . Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292 (2) :G512-7. |[4]Chauhan , et al. Therapeutic Modulation of Arginase with nor-NOHA Alters Immune Responses in Experimental Mouse Models of Pulmonary Tuberculosis including in the Setting of Human Immunodeficiency Virus (HIV) Co-Infection. Trop Med Infect Dis. 2024 Jun 6;9 (6) :129.