Merbromin

Merbromin is a mixed inhibitor of the 3-chymotrypsin-like protease (3CLpro) of SARS-CoV-2, with an IC50 of 2.7 μM. Merbromin effectively inhibits the replication of the Zika virus (ZIKV) and shows anti-ZIKV activity by inhibiting ZIKVpro. Merbromin can also be used as a topical disinfectant for cuts and scrapes, and it serves as a biological dye[1][2].

Product Specifications

CAS Number

[129-16-8]

Product Name Alternative

Mercury dibromofluorescein (disodium salt) ; ZP1

UNSPSC

12171500

Hazard Statement

H300, H310, H330, H373, H400, H410

Target

Flavivirus; Proteasome

Type

Dye Reagents

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Merbromin.html

Solubility

DMSO : 6.67 mg/mL (ultrasonic)

Smiles

O[Hg]C1=C(O[Na])C(Br)=CC(C2C3=C(C=CC=C3)C(O[Na])=O)=C1OC4=C2C=C(Br)C(O)=C4

Molecular Formula

C20H10Br2HgNa2O6

Molecular Weight

752.67

Precautions

H300, H310, H330, H373, H400, H410

References & Citations

[1]Xiangling Cui , et al. Identification of Theaflavin-3,3'-Digallate as a Novel Zika Virus Protease Inhibitor. Front Pharmacol. 2020 Oct 21;11:514313.|[2]Junjie Chen, et al. Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2. Biochem Biophys Res Commun. 2022 Feb 5:591:118-123.