Lapachol

Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity[1][2][3].

Product Specifications

CAS Number

[84-79-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lapachol-1.html

Concentration

10mM

Purity

99.49

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C(CC=C(C)C)=C1O)C2=CC=CC=C2C1=O

Molecular Formula

C15H14O3

Molecular Weight

242.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Raphael S Peres, et al. Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis. Arthritis Res Ther. 2017 Mar 7;19 (1) :47.|[2]Masayo Maeda, et al. Promotion or suppression of experimental metastasis of B16 melanoma cells after oral administration of lapachol. Toxicol Appl Pharmacol. 2008 Jun 1;229 (2) :232-8.|[3]Iasmin Aparecida Cunha Araújo, et al. Efficacy of lapachol on treatment of cutaneous and visceral leishmaniasis. Exp Parasitol. 2019 Apr:199:67-73.