MB05032
MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM.
Product Specifications
CAS Number
261365-11-1
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
FBPase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mb05032.html
Purity
99.63
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)CC1=C(C2=CC=C(P(O)(O)=O)O2)N=C(N)S1
Molecular Formula
C11H15N2O4PS
Molecular Weight
302.29
Precautions
H315, H319, H320
References & Citations
[1]Erion MD, et al. MB06322 (CS-917) : A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102 (22) :7970-5.|[2]Zhang Y, et al. Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells. Endocrinology. 2010 Oct;151 (10) :4688-95.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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