MB05032

MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM.

Product Specifications

CAS Number

[261365-11-1]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

FBPase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/mb05032.html

Purity

99.63

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)CC1=C(C2=CC=C(P(O)(O)=O)O2)N=C(N)S1

Molecular Formula

C11H15N2O4PS

Molecular Weight

302.29

Precautions

H315, H319, H320

References & Citations

[1]Erion MD, et al. MB06322 (CS-917) : A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102 (22) :7970-5.|[2]Zhang Y, et al. Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells. Endocrinology. 2010 Oct;151 (10) :4688-95.